The town of Neyyattinkara is well connected to the capital city of Thiruvananthapuram, 20 km away, through regular bus services operated by Kerala State Road Transport Corporation. Neyyattinkara KSRTC Bus Depot is the largest in the taluk and operates a wide array of services. These also include long-distance services to Guruvayoor, Thrissur, Kozhikode, Chakkulath Kaavu, Kollam, Ernakulam, Kanniyakumari, etc. A/C Low Floor buses frequently ply along the Neyyattinkara-East Fort-Medical College-Kazhakkuttam route. There are 24 hour bus service between Trivandrum to Nagarcoil via Neyyattinkara town and Nagarcoil to Trivandrum via Neyyattinkara town. Neyyattinkara Railway Station is located on the Mangalore- Trivandrum - Kanyakumari Railway line. Neyyattinkara railway station code is 'NYY'. Except Super Fast & weekly Trains, all other daily express trains and passenger trains through this route stops here. Thus the town is connected by major cities in India, including Chennai, Bangalore, Mumbai, Kolkata, Mangalore, Pune, etc.

The Trivandrum Central railway station is about (20 km) from the town. Express trains will take 15 minutes to reach Trivandrum city from Neyyattinkara town, however, passenger / Shuttle trains will take 30 minutes (since these trains have stops at Balaramapuram and Nemom in between Neyyattinkara Town and Trivandrum City). The nearest airport is Trivandrum International Airport, which is 23 km from the town.